Physicochemical Database

Pharmacists must routinely utilize chemical and physical characteristics of active ingredients, vehicles, and other materials for incorporation during the preparation of a prescription. Proper compounding of formulations indicates that each ingredient has been considered and evaluated as to physical compatibility; stability over a specified time; and concerns addressed as to the esthetic value and acceptability of the dosage form, odor, and palatability required by the human or animal patient. In other instances, the pharmacist may contemplate the utilization of a different strength from the original formula, vehicle, or flavor, or even changes for the packaging of the completed preparation.

During these considerations, the pharmacist is required to review several different references to develop the required chemical and physical information. The purpose of the Physicochemical Database is to provide a rapid and extensive reference of characteris-tics for chemicals, excipients, dietary supplements, and trade-marked products to make informed judgments on the proper preparation of compounded prescriptions.

This database provides information to assist pharmacists for proper choices in selecting official (USP-NF) materials, nonofficial, and commercial-branded products. Some guidelines and regulations for a specific chemical vary from country to country. Pharmacists must follow the regulations under which they are currently working.

Comments, suggestions or corrections, submit to: rbenischek@ijpc.com