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Chemotherapy Vial Reconstitution and Stability Database

Last Review: October 2005

Select a generic name by clicking on the name
Aldesleukin (Interleukin-2; IL-2) Allopurinol Amifostine
Asparaginase BCG, Intravesical Bleomycin
Bortezomib Carboplatin Carmustine
Cyclophosphamide Cytarabine arabinoside Dacarbazine
Dactinomycin Daunorubicin Dexrazoxane
Docetaxel Doxorubicin HCL Etoposide Phosphate
Floxuridine Fludaribine phosphate Gemcitabine
Gemtuzumab Idarubicin Ifosfamide
Mechlorethamine (Mustine) Melphalan Methotrexate sodium
Mitomycin Oxaliplatin Pentostatin (DCF)
Plicamycin Porfimer Sodium Rasburicase
Streptozocin Thiotepa Topotecan
Trastuzumab Vinblastine

Our Chemo Database features antineoplastic agents available in injectable powder form and that, therefore require reconstitution prior to use or being further diluted.

The Chemo Database lists the drug's generic name and the brands available in many countries. Information on reconstitution and physical and chemical stability of those medications however are related to the brand or generic available in the US. Manufacturers recommend limited storage for those drugs, which have limited stability. They also recommend discarding any unused portions of drugs. However, additional studies published by leading experts in the field of stability are also listed. It is essential to abide by the guidelines from the USP on the determination of beyond-use dates in aseptic compounding. Also, generally be sure that all solutions are clear before they are used.

Further dilution must be performed in a Class 100 biohazard cabinet or hood, and the preparer must wear proper protective gear. Many of these medications can be administered a number of different ways: intravenous infusion, intravenous push, intrathecally, intramuscularly, intra-arterially, subcutaneously, intrapleurally, and via isolation perfusion technique. A few of these medications require an intradermal skin test of an extreme dilution of the drug to determine the potential for an allergic reaction before a full dose of the medication is administered. The most common types of administration are intravenous infusion and intravenous push.

The beyond-use dating pertains to storage while the drug is left in the vial at the listed concentration. Other diluents in different amounts may be required to reconstitute a listed drug for administration via other routes. In these cases, please refer to the references listed below or to current published studies.