Brought to you by the International Journal of Pharmaceutical Compounding
March 24, 2006 Volume 3, Issue 12
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Spectrum Quality Assurance Seminar
  Letter from the Editor
Loyd V. Allen, Jr., Ph.D., R.Ph.
Editorial: European Association of Hospital Pharmacists in Geneva, Switzerland

IJPC is a part of the 11th Congress of the European Association of Hospital Pharmacists meeting being held this week in Geneva, Switzerland. The theme of the meeting is "Quality and Medication Safety Hand in Hand." About 2,000 pharmacists from 34 countries, including the US, are on hand, meeting and sharing; English is the language of the meeting.

IJPC has a very active exhibit at the meeting; evidenced by our running out of materials by yesterday (Thursday) afternoon. Many of the participants acknowledged that they already receive the Journal, which is highly valued in these European countries, and asked many questions about it.

This editor had the opportunity of presenting two sessions with Dr. Andras Vermes, Department of Clinical Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands. His topic was the European GMP Standards for hospital compounding (a special subset of GMP standards), and mine was on the New Standards for Sterile Compounding: USP Chapter <797> Pharmaceutical Compounding-Sterile Preparations. Because of the amount of interest in these topics, there were numerous questions after the sessions. Interestingly, in many hospitals in Europe, intravenous admixtures are still prepared by nurses on the wards; this is of great concern to the hospital pharmacists.

Other topics at the meeting included drug information exchange across European countries, documentation of pharmacists' interventions, realities of integrating automated medications systems in hospitals, stability of injectable drugs, TPN for neonates, barcoding and RFID scanning, evidence-based drug formularies, drug distribution systems, patient safety, pharmaceutical care software, and various other satellite symposia.

It is very interesting to share experiences with pharmacists from Europe and to know that although much of pharmacy is the same, we all have difficulties in our profession. Some of the difficulties are similar but many are different. Europe is unique as it consists of many countries with their own governments. Although they are generally under the European Union, they do not all share the same language, currency or laws pertaining to pharmacy. This diversity contributes to many problems that have to be dealt with in order to serve their patients.

Our congratulations to the organizing committees for an excellent program, superb facilities, and an outstanding job of putting it all together!


Loyd V. Allen, Jr., Ph.D., R.Ph
Editor-in-Chief

 
New Tool!

CompoundingToday.com Adds Oleaginous Vehicles Tool
Now you can find the following oleaginous vehicles and information about them on CompoundingToday.com:

  • Alkyl (C12-C15) Benzoate NF
  • Almond Oil NF
  • Coconut Oil
  • Corn Oil NF
  • Cottonseed Oil
  • Ethyl Oleate
  • Isopropyl Myristate
  • Isopropyl Palmitate
  • Mineral Oil
  • Mineral Oil, light
  • Octyldodecanol
  • Olive Oil
  • Peanut Oil
  • Safflower Oil
  • Sesame Oil
  • Soybean Oil
  • Squalane

Although most liquid pharmaceuticals are aqueous, a drug must often be formulated in a nonaqueous vehicle. For example, the drug may have limited water solubility, or it may not be stable in an aqueous vehicle. Drugs formulated in oil vehicles may have different release characteristics that result in a different onset and duration of action. Nonaqueous vehicles are routinely used for oral, topical, rectal, otic, nasal (limited), and parenteral formulations.

For this reason CompoundingToday.com has built this simple-to-use but comprehensive tool (details and references) for oleaginous vehicles used in pharmaceutical compounding. Try it today at CompoundingToday.com/OleaginousVehicle

 
Compounders Network List: Record Number of Postings in March

Nearly 200 topics were discussed by pharmacists and more than 550 e-mails were posted in March on the Compounders' Network List. Here are some of the topics discussed this week:

  • Mesotherapy Injection beyond-use date
  • Vitamin compounding
  • Therapies for cracked hands
  • Hyperadrenalism in animals
  • Insulin drip beyond-use dating
  • Oil capsule techniques
  • Oseltamivir suspension for animals
  • Pediatric compounding references
  • T3 subscriber needed for a patient in the Chicago, Illinois area

Tune in to this network of more than 1000 pharmacists worldwide. It's free. Just click here to get started CompoundingToday.com/CNL/.

 
CompoundingToday.com Citations and References Pulled from More than 800 Publications

CompoundingToday.com's literature search database consists of compiled literature citations and abstracts gathered from more than 800 medical and pharmacy publications. Only articles related to compounding are added to CompoundingToday.com's literature search database to help pharmacists find only the most relevant data more quickly.

Each week, article abstracts and citations are added based on topics discussed from the Compounders' Network List or topics about which subscribers have requested more information.

This week, the focus topic is migraine, principally alternative/complementary therapies and preventive therapies. A total of 58 articles have been included. Here is a sampling of some of the articles added:

  • Allais G, Bussone G, De Lorenzo C et al. Advanced strategies of short-term prophylaxis in menstrual migraine: State of the art and prospects. Neurol Sci 2005; 26(Suppl 2): S125-S129.
  • Boehnke C, Reuter U, Flach U et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: An open study in a tertiary care centre. Eur J Neurol 2004; 11(7): 475-477.
  • Cady RK, Schreiber CP, Beach ME et al. Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. Med Sci Monit 2005; 11(9): PI65-PI69.
  • Evans RW, Bigal ME, Grosberg B et al. Target doses and titration schedules for migraine preventive medications. Headache 2006; 46(1): 160-164.
  • Lipton RB, Gobel H, Einhaupl KM et al. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 2004; 63(12): 2240-2244.

 
Compounding Tip of the Week

Alcohol Alternatives
Need an alternative to alcohol for cleaning and disinfecting the laminar flow hood and isolation barrier unit? Use hydrogen peroxide 3% solution instead of isopropyl alcohol. It does take a little more time to dry but is very effective and safe for the surfaces, including any Plexiglas that may be a part of the unit.

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