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14‑DAY TRIAL    FORMULATIONS    MY ACCOUNT 
Compounding This Week Newsletter from www.CompoundingToday.com
Brought to you by IJPC
Our Compounding Knowledge, Your Peace of Mind
May 31, 2024  |  Volume 21  |  Issue 5
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IJPC May/June 2024 Issue

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FEATURE ARTICLES

IJPC May/Jun 2024, page 182 Bracketed Stability Evaluation of Methimazole USP in PLO Gel Mediflo™30 Pre-Mixed
Anh Tran, PhD, Kathryn Hunt, MSc, Claude Bernal III, BSc, Erica Cull, BSc


Extemporaneously compounded Methimazole 1% and 10% in PLO Gel Mediflo™30 Pre-Mixed were studied to assess physical, chemical and microbial stability over time. The formulations were stored at room temperature in tightly closed, light resistant plastic containers. Chemical stability was evaluated using a validated, stability indicating HPLC analysis and physical stability was evaluated through observation of organoleptic appearance and pH measurement at predetermined time points. Lastly, antimicrobial effectiveness testing was conducted per USP <51> guidelines.

IJPC May/Jun 2024, page 188 Heartworm-, Flea-, and Tick-associated Diseases in Dogs: A Review of Common Parasites and Drug Classes Prophylactic Against Them
Mike Riepl, RPh


For many veterinary patients, a customized preparation often proves to be the best therapeutic option, but many compounding-pharmacy stores also include a retail component that offers ready access to manufactured prescription medications, including those prophylactic against canine flea, tick, or heartworm infestation. Because dog owners often need guidance in selecting such products and assistance with obtaining them, this article will be of special interest to compounders in those pharmacies. To that end, the following content addresses common canine parasites and classes of drugs that prevent the illnesses they cause, with emphasis on heartworm disease.

IJPC May/Jun 2024, page 194 Compounding and Characterization of a Selfmicroemulsifying System of Ticagrelor Tablets for Enhanced Solubility
Rajagopal Kumaravelrajan, PhD, Narayanan Naresh, MPharm, Guru Prasad Mohanta, PhD, Suba Venkatesan, PhD, Pasupuleti Dharani Prasad, PhD


Ticagrelor is used to inhibit acute coronary syndrome, but its poor solubility and low bioavailability limit its in-vivo efficacy. The purpose of this study was to manufacture an optimized ticagrelor-loaded self-microemulsifying drug-delivery system in the form of tablets to enhance the solubility and dissolution of that drug.

IJPC May/Jun 2024, page 205 Prophylaxis Against Heartworm Infection and Flea or Tick Infestation in Dogs: Single Agents and Combination-Drug Products
Mike Riepl, RPh


Safe, effective antiparasitic prophylaxis in dogs remains a topic of major interest to both veterinarians and their clients, especially with respect to the prevention of canine heartworm infection and flea or tick infestation. Many compounders, especially those whose pharmacy includes a retail component, counsel veterinarians and pet owners about preparations and commercially available medications that prevent or treat parasitic infestations and provide assistance in obtaining those therapies. To support such efforts, this article provides information about single agents and combination-drug products prophylactic against common canine parasites, emerging resistance to those medications, and the toxic effects that such treatments can engender in some canine breeds.

IJPC May/Jun 2024, page 214 A Cross-sectional Online Questionnaire-based Survey About the Use of Compounded Medications in Veterinary Ophthalmology
Farah de Andrade, DVM, MSc, André Saldanha, DVM, MSc, João Thiago Bastos, DVM, Fabiano Montiani-Ferreira, DVM, MSc, PhD


The aims of this survey were to determine how veterinary ophthalmologists worldwide use compounded ophthalmic drugs to treat ocular diseases, define their attitudes regarding compounding pharmacies, and identify commonly dispensed veterinary ophthalmic formulations as well as the diseases for which those preparations are most often prescribed

IJPC May/Jun 2024, page 226 Recommended Tips for Treating Veterinary Patients
Bethany Bramwell, BS Pharm, RPh, LaVonn A. Williams


These recommended tips can be set up as free-of-charge, attractive pamphlets, which can either be given to the veterinary patient’s owner when medications are supplied or made available as a display.

Table of Contents
Complete contents, abstracts, page previews, and subscriber downloads are available on the IJPC Issue Page.

APPLIED COMPOUNDING

Basics of Sterile Compounding: Sterilization Methods in Sterile Product Manufacturing

PEER REVIEWED

STABILITY STUDY: Accelerated Stability Assessment of Extemporaneously Compounded Amiloride Nasal Spray

FORMULATIVE STUDY: Innovative Fusion of Probiotics and Mouth Fresheners: Investigating Unaltered Growth, Microscopic Analysis, and Mucoadhesive Strength

CASE REPORT: Case Report on the Effect of AlpaWash® on the Healing of a Post-surgical Wound in a Female Canine Initially Diagnosed with Pyometra

FORMULATIONS

Amlodipine Besylate Veterinary Suspension

Carprofen 2.5-mg/mL Oral Suspension, Veterinary

Diltiazem 5% in Lipoderm, Veterinary

Miconazole 1% Ophthalmic Solution, Veterinary

DEPARTMENTS

EDITORIAL/PRESCRIPTION: Veterinary

CALCULATIONS: Veterinary Products
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From Out of the Past

Don't leave safety
To mere chance
That's why
Belts are
Sold with pants
     Burma-Shave

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