Bracketed Stability Evaluation of Methimazole USP in PLO Gel Medifloâ„¢30 Pre-Mixed
Anh Tran, PhD, Kathryn Hunt, MSc, Claude Bernal III, BSc, Erica Cull, BSc

Extemporaneously compounded Methimazole 1% and 10% in PLO Gel Medifloâ„¢30 Pre-Mixed were studied to assess physical, chemical and microbial stability over time. The formulations were stored at room temperature in tightly closed, light resistant plastic containers. Chemical stability was evaluated using a validated, stability indicating HPLC analysis and physical stability was evaluated through observation of organoleptic appearance and pH measurement at predetermined time points. Lastly, antimicrobial effectiveness testing was conducted per USP <51> guidelines.

Heartworm-, Flea-, and Tick-associated Diseases in Dogs: A Review of Common Parasites and Drug Classes Prophylactic Against Them
Mike Riepl, RPh

For many veterinary patients, a customized preparation often proves to be the best therapeutic option, but many compounding-pharmacy stores also include a retail component that offers ready access to manufactured prescription medications, including those prophylactic against canine flea, tick, or heartworm infestation. Because dog owners often need guidance in selecting such products and assistance with obtaining them, this article will be of special interest to compounders in those pharmacies. To that end, the following content addresses common canine parasites and classes of drugs that prevent the illnesses they cause, with emphasis on heartworm disease.

Compounding and Characterization of a Selfmicroemulsifying System of Ticagrelor Tablets for Enhanced Solubility
Rajagopal Kumaravelrajan, PhD, Narayanan Naresh, MPharm, Guru Prasad Mohanta, PhD, Suba Venkatesan, PhD, Pasupuleti Dharani Prasad, PhD

Ticagrelor is used to inhibit acute coronary syndrome, but its poor solubility and low bioavailability limit its in-vivo efficacy. The purpose of this study was to manufacture an optimized ticagrelor-loaded self-microemulsifying drug-delivery system in the form of tablets to enhance the solubility and dissolution of that drug.

Prophylaxis Against Heartworm Infection and Flea or Tick Infestation in Dogs: Single Agents and Combination-Drug Products
Mike Riepl, RPh

Safe, effective antiparasitic prophylaxis in dogs remains a topic of major interest to both veterinarians and their clients, especially with respect to the prevention of canine heartworm infection and flea or tick infestation. Many compounders, especially those whose pharmacy includes a retail component, counsel veterinarians and pet owners about preparations and commercially available medications that prevent or treat parasitic infestations and provide assistance in obtaining those therapies. To support such efforts, this article provides information about single agents and combination-drug products prophylactic against common canine parasites, emerging resistance to those medications, and the toxic effects that such treatments can engender in some canine breeds.

A Cross-sectional Online Questionnaire-based Survey About the Use of Compounded Medications in Veterinary Ophthalmology
Farah de Andrade, DVM, MSc, André Saldanha, DVM, MSc, João Thiago Bastos, DVM, Fabiano Montiani-Ferreira, DVM, MSc, PhD

The aims of this survey were to determine how veterinary ophthalmologists worldwide use compounded ophthalmic drugs to treat ocular diseases, define their attitudes regarding compounding pharmacies, and identify commonly dispensed veterinary ophthalmic formulations as well as the diseases for which those preparations are most often prescribed

Recommended Tips for Treating Veterinary Patients
Bethany Bramwell, BS Pharm, RPh, LaVonn A. Williams

These recommended tips can be set up as free-of-charge, attractive pamphlets, which can either be given to the veterinary patient’s owner when medications are supplied or made available as a display.