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Compounding This Week Newsletter from www.CompoundingToday.com
Our Compounding Knowledge, Your Peace of Mind
July 29, 2022  |  Volume 19  |  Issue 30
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Loyd V. Allen, Jr., Ph.d., R.Ph Letter from the Editor
Cosmetics for Special Populations and for Use as Compounding Vehicles

Part 7: Example Cosmetic Formulas

We are continuing our series on "Compounding Cosmetics for Special populations and for Use as Compounding Vehicles." In this and next week's issues, we will look at example cosmetic formulations, their ingredients, and their purpose in the formulation.

The basic cosmetic formulations provided within this newsletter can be easily modified for different patient situations.

Note: CompoundingToday.com contains over 300 cosmetic formulas in 60 different categories available online to subscribers.


Loyd V. Allen, Jr., PhD, RPh
Editor-in-Chief

International Journal of Pharmaceutical Compounding
Remington: The Science and Practice of Pharmacy Twenty-second edition

Skin Care (Creams, Lotions, Powders)

  Hand Cream

Stearic acid 10 g Thickener
Lanolin 4 g Water Absorber
Glyceryl monostearate 4 g Emulsifier
Sorbitol 4 g Humectant
Span 60 4 g Emulsifier
Tween 60 1 g Emulsifier
Purified water qs 100 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the stearic acid, lanolin, and glyceryl monostearate using low heat.
  4. Add the sorbitol, Span 60, and Tween 80, and mix well.
  5. Heat the purified water to the same temperature, add to the sorbitol mixture, and mix using mechanical agitation until a smooth cream forms.
  6. Package and label the product.

  Hand and Body Lotion

Stearic acid 4 g Thickener
Lanolin 1 g Water Absorber
Triethanolamine 1 g Alkalizer
Mineral oil 6 g Vehicle
Purified water 88 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the stearic acid and lanolin using low heat, and add the mineral oil.
  4. Heat the purified water to the same temperature, and add the triethanolamine.
  5. Pour the aqueous phase (step 4) into the melted oil phase (step 3) with stirring.
  6. Stir the mixture until cool.
  7. Package and label the product.

  Dusting Powder

Kaolin 5 g Active
Zinc stearate 2 g Active
Zinc oxide 2 g Active
Magnesium carbonate 10 g Active
Menthol 0.05 g (optional) Perfume
Talc 81 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Dissolve the menthol in alcohol, using pulverization by intervention, spread over a pill tile or working surface, and allow it to dry.
  4. Mix the kaolin, zinc stearate, zinc oxide, magnesium carbonate, and talc separately.
  5. Sprinkle the powders over the menthol, and work the menthol into the powders by scraping it off the pill tile and blending it with the powders.
  6. Mix the mixture until uniform.
  7. Package and label the product.

Lipsticks and Medication Sticks

  Stick Formulation

White wax 10 g Thickener
White petrolatum 90 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the white wax in a beaker using low heat.
  4. Add the white petrolatum, and mix thoroughly with stirring rod until uniform.
  5. Cool the mixture until thick, and pour into ointment jar for storage at room temperature until used.
  6. Package and label the product.

  Soft Stick Formulation (Clear Stick Base)

Sodium stearate 10 g Vehicle
Alcohol 65 g Vehicle
Propylene glycol 25 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the sodium stearate using low heat.
  4. Mix the alcohol and propylene glycol, and add to the melted sodium stearate.
  5. Mix the mixture well, cool slightly, and pour into stick molds.
  6. Package and label the product.

  Blemish-hiding Stick

Stearic acid 20 g Thickener
Cetyl alcohol 25 g Thickener/Emulsifier
Potassium hydroxide 1 g Alkalizer
Purified water 3 g Solvent
Preservative 0.1 g Preservative
Titanium dioxide 14 g Coloring Agent
Calamine 0 to 2 g Coloring Agent
1% Sodium alginate solution qs 100 g Vehicle/Binding Agent
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the stearic acid and cetyl alcohol and heat to 70°C.
  4. Dissolve the potassium hydroxide in purified water, and warm to 70°C.
  5. Prepare the 1% sodium alginate solution in a separate container and heat to the same temperature.
  6. Mix the titanium dioxide and calamine with the hot sodium alginate solution and comminute the mixture.
  7. Add the potassium hydroxide solution (step 4) to the stearic acid-cetyl alcohol melt (step 3) with mechanical agitation, and then immediately add the sodium alginate-coloring agent dispersion (step 6).
  8. Continue stirring until the cream begins to thicken.
  9. Pour the cream into molds as desired.
  10. Package and label the product.

  Clear Shampoo

Triethanolamine lauryl sulfate 50 g Emulsifier
Polyoxyl 8 stearate 5 g Emulsifier
Purified water qs 100 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Mix the triethanolamine lauryl sulfate and polyoxyl 8 stearate in sufficient warm purified water to volume and mix well.
  4. Package and label the product.

  Cream Shampoo

Sodium lauryl sulfate 85 g Emulsifier
Polyoxyl 8 stearate 5 g Emulsifier
Magnesium stearate 2 g Thickener
Purified water 68 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Mix the sodium lauryl sulfate, polyoxyl 8 stearate, and magnesium stearate in warm purified water and mix well.
  4. Package and label the product.

Deodorants

  Deodorant Stick

Alcohol 56 mL Vehicle/Cosolvent
Purified water 4 mL Vehicle
Propylene glycol 5 g Vehicle/Cosolvent
Sodium stearate 4.25 g Vehicle/Stiffener
Perfume 0.2 g Perfume
Bacteriostatic agent qs as appropriate Preservative
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Heat the propylene glycol and sodium stearate to low heat and mix well.
  4. Add the purified water and the alcohol (to which the perfume, if used, is added), and mix well.
  5. Dissolve the bacteriostatic agent in either the alcohol or water phase, as appropriate.
  6. Pour the mixture into molds and allow to cool.
  7. Package and label the product.

  Liquid Deodorant/Antiperspirant

Alcohol 14 g Vehicle/Cosolvent
Purified water 71.75 g Vehicle
Glycerin 6 g Vehicle/Cosolvent
Aluminum chloride 8 g Active
Perfume qs as appropriate Perfume
Antibacterial agent qs Preservative
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Dissolve the aluminum chloride in the purified water.
  4. Mix the alcohol, glycerin, and perfume together.
  5. Add the aluminum chloride solution (step 3) to the alcohol solution (step 4) slowly with mixing.
  6. Add the bacterial agent to the appropriate phase before mixing.
  7. Mix well.
  8. Package and label the product.

  Deodorant Stick - Alcohol Free

Purified water 3% Vehicle/Solvent
Propylene glycol 10% Vehicle/Cosolvent
Deodorizer 1% Active
Sodium stearate 8% Vehicle/Thickener
PPG-3 myristyl ether 77% Emollient
Fragrance 1% Fragrance
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Heat the water and propylene glycol, while stirring, to about 60°C to 70°C.
  4. Add the deodorizer, sodium stearate, and PPG-3 myristyl ether, and mix well.
  5. Cool the mixture, add the fragrance while the mixture is still pourable, and mix until uniform.
  6. Pour the mixture into molds and allow to cool.
  7. Package and label the product.

Shaving Products

  Shave Cream (Brushless)

Stearic acid 12 g Thickener
Cetyl alcohol 2 g Emulsifier
Castor oil 2 g Emollient
Mineral oil, light 2 g Vehicle/Emollient
Lanolin 3 g Emollient
Tween 60 3 g Emulsifier
Span 60 1 g Emulsifier
Triethanolamine 1 g Alkalizer
Purified water qs 100 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Melt the stearic acid, cetyl alcohol, Tween 60, and Span 60, using low heat, and incorporate the castor oil, light mineral oil, and lanolin.
  4. Heat the purified water and triethanolamine to the same temperature.
  5. Mix the purified water mixture (step 4) with the stearic acid mixture (step 3), using mechanical agitation, until a nice smooth cream forms.
  6. Package and label the product.

Mouthwash

  Astringent Mouthwash

Sodium chloride 2.5 g Tonicity Adjuster
Zinc chloride 0.5 g Active
Menthol 0.05 g Active
Alcohol 9.6 g Solvent
Glycerin 10 g Cosolvent
Cinnamon oil 0.1 g Flavoring
Purified water qs 100 g Vehicle
  1. Calculate the required quantity of each ingredient for the total amount to be prepared.
  2. Weigh and/or measure each ingredient accurately.
  3. Dissolve the zinc chloride and sodium chloride in the purified water.
  4. Mix the alcohol, glycerin, menthol, and cinnamon oil together.
  5. Add the aqueous solution (step 3) to the alcohol solution (step 4) slowly with mixing.
  6. Package and label the product.
 

New Dosage Form Coming

Microneedle Arrays (MNAs), a new generation of transformative skin-mediated delivery systems, will soon be introduced as a new pharmaceutical dosage form,

Read about Microneedle Arrays and how to become involved with them in the upcoming issues of the International Journal of Pharmaceutical Compounding.

If not a current subscriber, subscribe online now to IJPC to see where compounding has new potential and opportunities. Call Deb at 800-757-4572 ext 1, or email at
IJPC-Subscriptions@IJPC.com

In the next three issues of IJPC, microneedle arrays will be discussed along with their potential use in compounding.

Sep/Oct 2022   Compounding with Microneedle Arrays, Part 1: Introduction and Overview
Nov/Dec 2022   Compounding with Microneedle Arrays, Part 2: Preparation, Compounding, and Recent Studies
Jan/Feb 2023   Compounding with Microneedle Arrays, Part 3: Preparation of Microneedle Array Blanks and Literature Examples

NOTE: This field is developing NOW! Check it out on MEDLINE/PubMed. Also, there is a "Microneedle and Transdermal Delivery Forum" scheduled to be held in Philadelphia on Sept. 13-14, 2022, with internationally known speakers working in this area.

 

Did You Know (On Time) ...

...the following?

"Half our life is spent trying to find something to do with the time we have rushed through life trying to save." (Will Rogers)

 

Thought of the Week (On Time)

"Remember the old days when people killed time by working instead of by coffee breaks?" (Anon)

"To my mind, the best investment a young man starting out in business can make is to give all his time, all his energies to work, just plain, hard, work." (C. Schwab)

"Time wounds all heels." (Anon)

"The deliberate gift of time to yourself each day is to do what gives you the greatest satisfaction, even if that means doing nothing at all." (Anon)

 

Join the CNL!

IJPC would like to invite all compounding pharmacists and technicians to join the Compounders' Network List (CNL) - an e-mail-based resource for sharing compounding information with your peers.

Go to the following website for more information and to join.

https://ijpc.com/cnl

 

From Out of the Past

Around
The curve
Likety-split
A beautiful car'
Wasn't it!
     Burma-Shave

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