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| Cosmetics for Special Populations and for Use as Compounding Vehicles |
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Part 7: Example Cosmetic Formulas
We are continuing our series on "Compounding Cosmetics for Special populations and for Use as Compounding Vehicles." In this and next week's issues, we will look at example cosmetic formulations, their ingredients, and their purpose in the formulation.
The basic cosmetic formulations provided within this newsletter can be easily modified for different patient situations.
Note: CompoundingToday.com contains over 300 cosmetic formulas in 60 different categories available online to subscribers.
Loyd V. Allen, Jr., PhD, RPh
Editor-in-Chief
International Journal of Pharmaceutical Compounding
Remington: The Science and Practice of Pharmacy Twenty-second edition
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Skin Care (Creams, Lotions, Powders)
Hand Cream
Stearic acid | 10 g | Thickener |
Lanolin | 4 g | Water Absorber |
Glyceryl monostearate | 4 g | Emulsifier |
Sorbitol | 4 g | Humectant |
Span 60 | 4 g | Emulsifier |
Tween 60 | 1 g | Emulsifier |
Purified water | qs 100 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the stearic acid, lanolin, and glyceryl monostearate using low heat.
- Add the sorbitol, Span 60, and Tween 80, and mix well.
- Heat the purified water to the same temperature, add to the sorbitol mixture, and mix using mechanical agitation until a smooth cream forms.
- Package and label the product.
Hand and Body Lotion
Stearic acid | 4 g | Thickener |
Lanolin | 1 g | Water Absorber |
Triethanolamine | 1 g | Alkalizer |
Mineral oil | 6 g | Vehicle |
Purified water | 88 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the stearic acid and lanolin using low heat, and add the mineral oil.
- Heat the purified water to the same temperature, and add the triethanolamine.
- Pour the aqueous phase (step 4) into the melted oil phase (step 3) with stirring.
- Stir the mixture until cool.
- Package and label the product.
Dusting Powder
Kaolin | 5 g | Active |
Zinc stearate | 2 g | Active |
Zinc oxide | 2 g | Active |
Magnesium carbonate | 10 g | Active |
Menthol | 0.05 g (optional) | Perfume |
Talc | 81 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Dissolve the menthol in alcohol, using pulverization by intervention, spread over a pill tile or working surface, and allow it to dry.
- Mix the kaolin, zinc stearate, zinc oxide, magnesium carbonate, and talc separately.
- Sprinkle the powders over the menthol, and work the menthol into the powders by scraping it off the pill tile and blending it with the powders.
- Mix the mixture until uniform.
- Package and label the product.
Lipsticks and Medication Sticks
Stick Formulation
White wax | 10 g | Thickener |
White petrolatum | 90 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the white wax in a beaker using low heat.
- Add the white petrolatum, and mix thoroughly with stirring rod until uniform.
- Cool the mixture until thick, and pour into ointment jar for storage at room temperature until used.
- Package and label the product.
Soft Stick Formulation (Clear Stick Base)
Sodium stearate | 10 g | Vehicle |
Alcohol | 65 g | Vehicle |
Propylene glycol | 25 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the sodium stearate using low heat.
- Mix the alcohol and propylene glycol, and add to the melted sodium stearate.
- Mix the mixture well, cool slightly, and pour into stick molds.
- Package and label the product.
Blemish-hiding Stick
Stearic acid | 20 g | Thickener |
Cetyl alcohol | 25 g | Thickener/Emulsifier |
Potassium hydroxide | 1 g | Alkalizer |
Purified water | 3 g | Solvent |
Preservative | 0.1 g | Preservative |
Titanium dioxide | 14 g | Coloring Agent |
Calamine | 0 to 2 g | Coloring Agent |
1% Sodium alginate solution | qs 100 g | Vehicle/Binding Agent |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the stearic acid and cetyl alcohol and heat to 70°C.
- Dissolve the potassium hydroxide in purified water, and warm to 70°C.
- Prepare the 1% sodium alginate solution in a separate container and heat to the same temperature.
- Mix the titanium dioxide and calamine with the hot sodium alginate solution and comminute the mixture.
- Add the potassium hydroxide solution (step 4) to the stearic acid-cetyl alcohol melt (step 3) with mechanical agitation, and then immediately add the sodium alginate-coloring agent dispersion (step 6).
- Continue stirring until the cream begins to thicken.
- Pour the cream into molds as desired.
- Package and label the product.
Clear Shampoo
Triethanolamine lauryl sulfate | 50 g | Emulsifier |
Polyoxyl 8 stearate | 5 g | Emulsifier |
Purified water | qs 100 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Mix the triethanolamine lauryl sulfate and polyoxyl 8 stearate in sufficient warm purified water to volume and mix well.
- Package and label the product.
Cream Shampoo
Sodium lauryl sulfate | 85 g | Emulsifier |
Polyoxyl 8 stearate | 5 g | Emulsifier |
Magnesium stearate | 2 g | Thickener |
Purified water | 68 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Mix the sodium lauryl sulfate, polyoxyl 8 stearate, and magnesium stearate in warm purified water and mix well.
- Package and label the product.
Deodorants
Deodorant Stick
Alcohol | 56 mL | Vehicle/Cosolvent |
Purified water | 4 mL | Vehicle |
Propylene glycol | 5 g | Vehicle/Cosolvent |
Sodium stearate | 4.25 g | Vehicle/Stiffener |
Perfume | 0.2 g | Perfume |
Bacteriostatic agent | qs as appropriate | Preservative |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Heat the propylene glycol and sodium stearate to low heat and mix well.
- Add the purified water and the alcohol (to which the perfume, if used, is added), and mix well.
- Dissolve the bacteriostatic agent in either the alcohol or water phase, as appropriate.
- Pour the mixture into molds and allow to cool.
- Package and label the product.
Liquid Deodorant/Antiperspirant
Alcohol | 14 g | Vehicle/Cosolvent |
Purified water | 71.75 g | Vehicle |
Glycerin | 6 g | Vehicle/Cosolvent |
Aluminum chloride | 8 g | Active |
Perfume | qs as appropriate | Perfume |
Antibacterial agent | qs | Preservative |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Dissolve the aluminum chloride in the purified water.
- Mix the alcohol, glycerin, and perfume together.
- Add the aluminum chloride solution (step 3) to the alcohol solution (step 4) slowly with mixing.
- Add the bacterial agent to the appropriate phase before mixing.
- Mix well.
- Package and label the product.
Deodorant Stick - Alcohol Free
Purified water | 3% | Vehicle/Solvent |
Propylene glycol | 10% | Vehicle/Cosolvent |
Deodorizer | 1% | Active |
Sodium stearate | 8% | Vehicle/Thickener |
PPG-3 myristyl ether | 77% | Emollient |
Fragrance | 1% | Fragrance |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Heat the water and propylene glycol, while stirring, to about 60°C to 70°C.
- Add the deodorizer, sodium stearate, and PPG-3 myristyl ether, and mix well.
- Cool the mixture, add the fragrance while the mixture is still pourable, and mix until uniform.
- Pour the mixture into molds and allow to cool.
- Package and label the product.
Shaving Products
Shave Cream (Brushless)
Stearic acid | 12 g | Thickener |
Cetyl alcohol | 2 g | Emulsifier |
Castor oil | 2 g | Emollient |
Mineral oil, light | 2 g | Vehicle/Emollient |
Lanolin | 3 g | Emollient |
Tween 60 | 3 g | Emulsifier |
Span 60 | 1 g | Emulsifier |
Triethanolamine | 1 g | Alkalizer |
Purified water | qs 100 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Melt the stearic acid, cetyl alcohol, Tween 60, and Span 60, using low heat, and incorporate the castor oil, light mineral oil, and lanolin.
- Heat the purified water and triethanolamine to the same temperature.
- Mix the purified water mixture (step 4) with the stearic acid mixture (step 3), using mechanical agitation, until a nice smooth cream forms.
- Package and label the product.
Mouthwash
Astringent Mouthwash
Sodium chloride | 2.5 g | Tonicity Adjuster |
Zinc chloride | 0.5 g | Active |
Menthol | 0.05 g | Active |
Alcohol | 9.6 g | Solvent |
Glycerin | 10 g | Cosolvent |
Cinnamon oil | 0.1 g | Flavoring |
Purified water | qs 100 g | Vehicle |
- Calculate the required quantity of each ingredient for the total amount to be prepared.
- Weigh and/or measure each ingredient accurately.
- Dissolve the zinc chloride and sodium chloride in the purified water.
- Mix the alcohol, glycerin, menthol, and cinnamon oil together.
- Add the aqueous solution (step 3) to the alcohol solution (step 4) slowly with mixing.
- Package and label the product.
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New Dosage Form Coming
Microneedle Arrays (MNAs), a new generation of transformative skin-mediated delivery systems, will soon be introduced as a new pharmaceutical dosage form,
Read about Microneedle Arrays and how to become involved with them in the upcoming issues of the International Journal of Pharmaceutical Compounding.
If not a current subscriber, subscribe online now to IJPC to see where compounding has new potential and opportunities.
Call Deb at 800-757-4572 ext 1, or email at IJPC-Subscriptions@IJPC.com
In the next three issues of IJPC, microneedle arrays will be discussed along with their potential use in compounding.
Sep/Oct 2022 | | Compounding with Microneedle Arrays, Part 1: Introduction and Overview |
Nov/Dec 2022 | | Compounding with Microneedle Arrays, Part 2: Preparation, Compounding, and Recent Studies |
Jan/Feb 2023 | | Compounding with Microneedle Arrays, Part 3: Preparation of Microneedle Array Blanks and Literature Examples |
NOTE: This field is developing NOW! Check it out on MEDLINE/PubMed. Also, there is a "Microneedle and Transdermal Delivery Forum" scheduled to be held in Philadelphia on Sept. 13-14, 2022, with internationally known speakers working in this area.
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Did You Know (On Time) ...
...the following?
"Half our life is spent trying to find something to do with the time we have rushed through life trying to save." (Will Rogers)
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Thought of the Week (On Time)
"Remember the old days when people killed time by working instead of by coffee breaks?" (Anon)
"To my mind, the best investment a young man starting out in business can make is to give all his time, all his energies to work, just plain, hard, work." (C. Schwab)
"Time wounds all heels." (Anon)
"The deliberate gift of time to yourself each day is to do what gives you the greatest satisfaction, even if that means doing nothing at all." (Anon)
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Join the CNL!
IJPC would like to invite all compounding pharmacists and technicians to join the Compounders' Network List (CNL) - an e-mail-based resource for sharing compounding information with your peers.
Go to the following website for more information and to join.
https://ijpc.com/cnl
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From Out of the Past
Around
The curve
Likety-split
A beautiful car'
Wasn't it!
Burma-Shave
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