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IJPC: Our Compounding Knowledge - Your Peace of Mind!

Microbial Solutions for Compounders from Charles River


		March/April 2018 Issue of IJPC

The following is the content for the March/April 2018 issue of the International Journal of Pharmaceutical Compounding (IJPC).

Editorial
	Drug Quality and Security Act Implementation Subcommittee Hearing

Features
Pharmacogenomics: Precision Pharmacy in 503A Compounding Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management The IACP Testifies at U.S. House of Representatives' Energy & Commerce Health Subcommittee Pharmacy Compounding Hearing

Basics of Nonsterile Compounding
	Compounding Microemulsions

Quality Control and Basics of Sterile Compounding
	Lessons Learned from a Trimix Stability Study in a 503A Compounding Pharmacy

Calculations

Formulations
	Clonidine Hydrochloride 10 ï¿½g/mL in InOrpha Solution
	Dorzolamide 2% and Timolol 0.5% Ophthalmic Solution
	Lamotrigine 1-mg/mL in SyrSpend SF PH4 Oral Suspension
	Levodopa and Carbidopa Rectal Suspension
	Prochlorperazine Edisylate 0.5% Nasal Spray
	Rolapitant Injectable Emulsion with Palonosetron Hydrochloride Admixture
	Spironolactone 5-mg/mL in SuspendIt Oral Suspension
	Trilostane 5-mg/mL in Cod Liver Oil Suspension (Vet)

Peer Review
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats The Influence of Tablet Formulation, Drug Concentration, and pH Modification on the Stability of Extemporaneously Compounded Levothyroxine Suspensions Topical Ketamine in the Treatment of Complex Regional Pain Syndrome

NOTE: If you wish to subscribe or need help navigating the following online websites, please email Deb at subscription-info@ijpc.com or call the IJPC office at 800.757.4572 x1:

Loyd V. Allen, Jr., PhD, RPh
Editor-in-Chief
International Journal of Pharmaceutical Compounding
Remington: The Science and Practice of Pharmacy Twenty-second edition

Announcement

USP Seeking Input on Revisions to Chapters <795> and <797>.

The USP has released a timeline for the proposed revisions:

The public comment period for <795> will occur between March 30, 2018 and July 31, 2018.
The public comment period for <797> will occur between July 27, 2018 and November 30, 2018.

Note: The hazardous drug handling sections in <795> and <797> will reference General Chapter <800>.

The three chapters are expected to be official on December 1, 2019.

Click below to view the timeline associated with the proposed revisions and for opportunities to provide input.

http://www.usp.org/compounding/updates-on-standards

News

The following is the FDA's current list of drug shortages.

Amino Acids	Labetalol Hydrochloride Injection
Aminocaproic Acid Injection, USP	Leucovorin Calcium Lyophilized Powder for Injection
Amoxapine Tablets	Lidocaine Hydrochloride (Xylocaine) and Dextrose Injection Solution-Premix Bags
Asparaginase Erwinia Chrysanthemi (Erwinaze)	Lidocaine Hydrochloride (Xylocaine) Injection
Atenolol Tablets	Lidocaine Hydrochloride (Xylocaine) Injection with Epinephrine
Atropine Sulfate Injection	Liotrix (Thyrolar) Tablets
Belatacept (Nulojix) Lyophilized Powder for Injection	Methotrexate Sodium Injection
Betaine Hydrochloride (Cystadane) for Oral Solution	Methylphenidate Hydrochloride (QUILLICHEW ER) Extended-Release Chewable Tablets
Bleomycin Sulfate for Injection	Methylphenidate Hydrochloride (QUILLIVANT XR) Extended-Release Oral Suspension
Bumetanide Injection, USP	Metoclopramide Injection, USP
Bupivacaine Hydrochloride and Epinephrine Injection, USP	Metronidazole Injection, USP
Bupivacaine Hydrochloride Injection, USP	Molindone Hydrochloride Tablets
Calcium Chloride Injection, USP	Morphine Sulfate Injection, USP
Calcium Gluconate Injection	Multi-Vitamin Infusion (Adult and Pediatric)
Carbidopa and Levodopa Extended Release Tablets	Mupirocin Calcium Nasal Ointment
Cefepime Injection	Nitrous Oxide, Gas
Cefotaxime Sodium (Claforan) Injection	Pantoprazole (Protonix) Powder for Injection
Cefotetan Disodium Injection	Penicillamine (Depen) Titratable Tablets
Cromolyn Sodium Inhalation Solution, USP	Penicillin G Benzathine (Bicillin L-A) Injection
Deferoxamine Mesylate for Injection, USP	Penicillin G Benzathine and Penicillin G Procaine (Bicillin C-R) Injection
Dexrazoxane Injection	Penicillin G Procaine Injection
Dextrose 5% Injection Bags	Peritoneal Dialysis Solutions
Dextrose 50% Injection	Phosphate Injection Products
Diazepam Injection, USP	Piperacillin and Tazobactam (Zosyn) Injection
Dihydroergotamine Mesylate Injection	Potassium Chloride Injection
Diltiazem Hydrochloride	Potassium Phosphate Injection
Disopyramide Phosphate (Norpace) Capsules	Procainamide Hydrochloride Injection, USP
Dobutamine Hydrochloride Injection	Progesterone Injection, USP
Dopamine Hydrochloride Injection	Promethazine (Phenergan) Injection
Dorzolamide Hydrochloride and Timolol Maleate (Cosopt) Ophthalmic Solution	Ranitidine Injection, USP
Dorzolamide Hydrochloride Ophthalmic Solution	Remifentanil (Ultiva) Lyophilized Powder for Solution Injection
Epinephrine Injection, 0.1 mg/mL	Rocuronium Bromide Injection
Ethiodized Oil (Lipiodol) Injection	Sacrosidase (Sucraid) Oral Solution
Etoposide Injection	Sclerosol Intrapleural Aerosol
Etoposide Phosphate (Etopophos) Injection	Sincalide (Kinevac) Lyophilized Powder for Injection
Fentanyl Citrate (Sublimaze) Injection	Sodium Acetate Injection, USP
Fluorescein Strips	Sodium Bicarbonate Injection, USP
Folic Acid Injection	Sodium Chloride 0.9% Injection Bags
Gemifloxacin Mesylate (Factive) Tablets	Sodium Chloride 23.4% Injection
Guanfacine Hydrochloride Tablets	Sodium Phosphate Injection
Heparin Sodium and Sodium Chloride 0.9% Injection	Sterile Talc Powder
Hydromorphone Hydrochloride Injection, USP	Sterile Water
Imipenem and Cilastatin for Injection, USP	Technetium Tc99m Succimer Injection (DMSA)
Ketamine Injection	Theophylline Extended-Release Tablets and Capsules
L-Cysteine Hydrochloride Injection	Thioridazine Hydrochloride Tablets

https://www.accessdata.fda.gov/scripts/drugshortages/default.cfm

Did You Know ...

ï¿½that Will Rogers said the following?

"I don't make jokes. I just watch the government and report the facts."

Tip of the Week

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Looking Back

Keep well to the right,
Of the oncoming car,
Get your close shaves
From the half-pound jar!
Burma Shave


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