|
Continuing our BCS topic, this week we will look at a summary of the BCS and the BDDCS. Recall that the BCS is developed based on solubility and permeability, and the BDDCS is based on solubility and metabolism. They can be placed in a table such as the following:
| Class 1 | High Solubility | High Permeability | Extensive Metabolism |
| Class 2 | Low Solubility | High Permeability | Extensive Metabolism |
| Class 3 | High Solubility | Low Permeability | Poor Metabolism |
| Class 4 | Low Solubility | Low Permeability | Poor Metabolism |
Note: The information in column 2 applies to both BCS and BDDCS. The information in column 3 (red) applies to BCS, and the information in column 4 (green) applies to BDDCS.
BCS: Dissolution and GI permeability are the fundamental parameters controlling the rate and extension of drug absorption.
BDDCS: Includes the effect of food, absorptive transporters, efflux transporters, and routes of elimination (renal/biliary) on overall drug absorption and bioavailability for immediate-release oral dosage forms, which is more than just the permeability.
Next week: New drug development, regulatory drug approval, and "biowaivers."
Loyd V. Allen, Jr., PhD, RPh
Editor-in-Chief
International Journal of Pharmaceutical Compounding
Remington: The Science and Practice of Pharmacy Twenty-second edition
| 
