(Learning about USP Chapter <800> in 10 minutes a week.)

15. DEACTIVATING, DECONTAMINATING, CLEANING, AND DISINFECTING

Nonsterile Areas: Deactivation, Decontamination, Cleaning

Sterile Areas: Deactivation, Decontamination, Cleaning, Disinfection

• SOPs needed
• Training required
• Appropriate PPE resistant to cleaning agents used must be worn, including two pairs of chemo gloves and impermeable disposable gowns
• Eye protection and face shields required if splashing is likely
• Respiratory protection if warranted
• Use wetted wipes and not spray bottle for surfaces
• Dispose of materials properly

15.1 Deactivation

• Render compound inert or inactive
• No single method for deactivating all compounds
• Oxidizing agents generally used

15.2 Decontamination

• Remove HD residue
• Inactivate, neutralize, or physically remove the HD residue
• Includes work surface and under the "work trays" where residue may collect

15.3 Cleaning

• Remove organic and inorganic material
• Uses water, detergents, surfactants, solvents, and/or other chemicals
• Not to be performed with compounding activities are occurring

15.4 Disinfection

• Destroy microorganisms
• Required for surfaces where sterile compounding occurs

QUESTIONS

For a full list of questions for which we are awaiting answers from USP, please go to: http://www.ijpc.com/USP800Questions

We will announce when the answers have been received and posted.

Loyd V. Allen, Jr., PhD, RPh
Editor-in-Chief
International Journal of Pharmaceutical Compounding
Remington: The Science and Practice of Pharmacy Twenty-second edition

News

FDA Requests Cabinet-level Powers
Six former FDA commissioners have called upon Congress to make the agency independent, increasing its profile and power, and taking it out from under DHHS. They are requesting autonomy similar to the FTC or the Securities and Exchange Commission.

See http://www.politico.com/story/2016/06/former-commissioners-make-fda-a-cabinet-level-agency-224803

(Editor's note: You've got to be kidding! Definitely a bad idea for healthcare professionals and patients.)

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Did You Know ...

�that standard drug concentrations for compounded oral liquids have been voluntarily developed for pediatric patients in the state of Michigan?

Tip of the Week

Respondents to a survey on the new standard drug concentrations indicated they believe the standards will improve pediatric patient safety, and 48% of pharmacists reported that they had adopted at least 50% of the standard concentrations. [AJHP 2016; 73(13): 981-990].

Looking Back

The cream preserves
Pa's razor blade,
The jar preserves
Ma's marmalade!
     Burma Shave

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• All chapters have been updated
• Several chapters have been significantly revised-particularly "Compounding with Hazardous Drugs", and
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