Book Review

The Wrinkle Cure

Nicholas Perricone, MD
Rodale Reach

This is an excellent book for those interested in compounding, dispensing, or recommending cosmeceuticals and for readers who want to understand more about those products and how they work. The author, a physician, begins his book by explaining the aging process of the skin according to ethnicity, skin tone, and skin type. He then explains his aggressive program to “halt the visible signs of aging.” His program includes the use of vitamin C esters, a-lipoic acid, dimethylaminoethanol (DMAE), tocotrienols (a high-potency form of vitamin E), and a-hydroxy and ß-hydroxy acids. He also advocates a lifestyle incorporating healthful living habits; exercise; and a diet rich in vegetables, fruits, lean meat, and salmon. In his program, vitamin C, an antioxidant, is used to reduce fine lines and wrinkles on severely sun-damaged skin; to improve the texture of sagging skin that is losing its firmness because of lost or damaged collagen; and to treat sunburned, in- flamed, or irritated skin. The antioxidant and anti-inflammatory a-lipoic acid is used to treat problems such as lines and wrinkles, undereye bags and puffiness, enlarged pores, acne scars, and sallow or dull skin. It is used to treat those prone to allergic reactions caused by other types of skin products. DMAE, an antioxidant membrane stabilizer, is found in fish. It is used to enhance the strength of other antioxidant therapies and to correct loss of firmness in the skin of the face or body, to reduce fine lines above and below the lips, to improve the texture of stressed or overtired skin, and to enable thin lips to look fuller and more defined. The tocotrienol form of vitamin E is used in those treatments because it is 40 to 50 times stronger than a-tocopherol or a formula of mixed tocopherols and is more effective in repairing skin damage and banishing free radicals. Alpha-hydroxy and ß-hydroxy acids are used to improve the effectiveness of other skin treatment products and to treat razor bumps; rough, dry, or finely lined skin; and uneven pigmentation (age spots). This book is an excellent resource for pharmacists who are interested in incorporating the ingredients mentioned into current compounds or in creating new compounds for individual patient needs. Participants in the BioCosmeticology Program, which is offered by Professional Compounding Centers of America, will find this text helpful.


Reviewed By:  Dana Reed-Kane, PharmD, FIACP, FACA, FCP, NFPPhC
In:  Mar/Apr 2002